biodosetools 3.7.1
CRAN release: 2025-10-22
- New module for criticality accidents dose estimation.
- New module for calculating chacaracteristic limits.
- New module for interlaboratory comparisons.
biodosetools 3.6.1.1
- Updated citation details for {biodosetools} after publication in Int J Radiat Biol (doi:10.1080/09553002.2023.2176564).
- Improvements in
deploy-shiny.ymlCI workflow. - Added
dev/shiny-redirectshiny app to redirectbiodosetools-v3at shinyapps.io to version hosted by Bundesamt für Strahlenschutz.
biodosetools 3.6.1
CRAN release: 2022-11-16
- Removed {pkgload} and {htmltools} as package dependencies.
- Server modules now use
moduleServer(), as recommended in {shiny} >= 1.5.0 (see https://shiny.rstudio.com/articles/modules.html). - Updated
golem_utils_ui.Rand related unit tests to match {golem} 0.3.x (see https://github.com/ThinkR-open/golem/commit/61b9063f65006bc9b15dd2f1e535466c45d25424). - Updated CITATION file.
- Updated vignettes.
Improvements
- Updated LQ and L formulas to use lambda instead of Y for yield in
parse_model_formula(),list_fitting_formulas(), and help dialogues. - Removed unnecessary {base} namespace in
solve()call. - Removed legacy
gardner_confidence_tabledata (deprecated in 585e7b4). - Updated
get_cov_ZIP_ML()to match expressions on manuscript, introducing minor calculation optimisation. - Improved
fit_maxlik_method()by removing unused local variables and redundant calls. - Switched
message()tocli::cli_alert_warning()infit()function when switching fromglm()to ML optimization. - Updated
match_names()to return inputx, akin tomatch.arg()from {base}. - Updated default values for assessment and whole-body error method selection in
mod_estimation_micro_ui(). - Added
meanandstd_errcolumn renaming tocalculate_aberr_table()whentype = "case"depending on newaberr_moduleparameter. - Added
aberr_modulevalidation usingmatch.arg()in*_aberr_table(),estimate_*(),prepare_maxlik_count_data(),fit*()functions. - Updated unit tests for
names_from_model_formula()andparse_model_formula(). - Updated
app_config.Randtest-golem-recommended.Runit tests. - Added unit test for
load_rmd_report(). - Added basic
testServer()unit tests for allmod_*_server()modules.
UI Improvements
- Updated “Irradiation conditions” boxes so they are no longer collapsed by default in
mod_fitting_*_ui.Rmodules.
Bug fixes
- Return case data
as_tibble()incalculate_aberr_table()for consistency with count data. - Minor formatting fix in
cli::cli_alert_info()call. - Fixed
pi_estimatevalue inest_metaphases_fracdata frame inestimate_partial_body_dolphin(), as pointed out by Gaëtan. - Fixed issue with
match_names()not correctly stopping, and added unit tests for it. - Fixed misconstructed column selection in
calculate_aberr_table()whentype = "case". - Added
est_metaphases_fracdata frame to explicitly returnf (1 - pi_est)inestimate_partial_body_dolphin()(closes #29). - Updated deprecated
.datacalls inside {tidyselect} selections (see https://www.tidyverse.org/blog/2022/10/tidyselect-1-2-0/).
Deprecations
- Removed unused files in
data-raw. - Deprecated
model_formulawith no intercept inparse_model_formula(),names_from_model_formula(),prepare_maxlik_count_data(),fit_maxlik_method(), andmod_estimation_fit_curve_hot_server(). - Removed
golem_utils_server.R. - Purged
calculate_decision_threshold*()functions and mentions in UI and server modules, as this will be rewritten from scratch. - Removed
calculate_decision_thresholdfrom_pkgdown.yml.
biodosetools 3.6.0
CRAN release: 2022-01-27
- Major rewrite of
plot_estimated_dose_curve()function. - Delta method calculations are now all done via
msm::deltamethod(). - Added progress and alert notifications to UI.
- Added {markdown} as suggested dependency.
- Added {cli} as dependency.
- Tweaked references section in {pkgdown} site to only include exported functions organised by topic/usage.
- Use consistently genomic conversion factor or
genome_factoracross all functions, help dialogues, and reports. - Added R-CMD check GitHub Action.
- Added vignettes.
New features
- Return
conf_intinestimate_*()family of functions. - Parse
est_full_doses$typeinplot_estimated_dose_curve()function so unused assessments are not shown in legend. - Added
match_names()function to match est_doses list names when callingplot_estimated_dose_curve(). - Updated
plot_estimated_dose_curve()to automatically buildest_full_dosesobject from list of dose estimation results, addedparse_conf_int_text()auxiliary function.
Bug fixes
- Correct dispersion index value on
estimate_whole_body_delta()when there’s no aberrations. - Fixed issue in missing count data in DOCX fitting report.
- Removed double calculation of
cov_estinestimate_partial_dolphin(). - Wrapped mixed Poisson model dose estimation in
try()to ensure convergence (up to 5 tries). - Mixed Poisson model
estimate_hetero_mixed_poisson()uses exact delta methods for dose and fraction irradiated, as described in paper by Pujol et al. (2016) https://doi.org/10.1667/RR14145.1. - Fixed
gammaandgamma_errorparsing when callingestimate_hetero_mixed_poisson()inmod_estimation_results_server(). - Wrap unicode characters (
\uxxxx) inrlang::as_utf8_character()to avoid “unable to translate to native encoding” warning on Windows.
New functions
-
get_deltamethod_std_err(): auxiliary function to wrap allmsm::deltamethod()calls.
Improvements
- Fixed order of output case data columns in
calculate_aberr_table()so they match the final output in Shiny. - Renamed
count-data-IAEA.csvtocount-data-barquinero-1995.csvfrom Barquinero et al. (1995) https://doi.org/10.1016/0027-5107(94)00150-4. - Added
count-data-rodriguez-2004.csvfor total translocations from Rodriguez et al. (2004) https://doi.org/10.1667/RR3198. - Updated translocations fitting unit tests to use data from Rodriguez et al. (2004) https://doi.org/10.1667/RR3198.
- Rewrote
calculate_aberr_power()to remove {purrr} dependency and reduce computation time by 4. - Replaced
message()calls with appropriatecli::cli_*()calls. - Split quasi-Poisson from automatic fitting in
fit_glm_method(), as it is otherwise confusing. - Updated
\sigmato\hat{\sigma}infix_count_data_names()and respective tests. - Updated unit tests to test individual values both in dose-effect fitting and dose estimation.
- Use
*-fitting-results-*.rdsinstead of*-fitting-data-*.rdswhen exporting RDS objects inmod_fitting_results_server().
UI Improvements
- Added new
side-widget-*CSS classes to better style file download/format buttons. - Added
widget_sep_vert()function. - Use new
sep-widget_*CSS classes in fitting UI modules. - Updated report help modals text.
- Using new
side-widget-*CSS classes in dose estimation UI modules. - Added progress notifications to calculations via
shiny::Progress. - Updated
_pkgdown.ymland simplifiedextra.cssthanks to Bootstrap 5 support in {pkgdown} 2.0.0.
biodosetools 3.5.0 (2021-05-26)
- Added unit tests for to check code coverage and to validate that the code performs as expected.
- Major revision of the fitting and dose estimation pipelines, introducing new auxiliary functions to reduce duplicated code.
- Major simplification of report rendering process; abandoned HTML output.
- Added custom {pkgdown} theme for more consistent branding.
- Added preliminary citation to README.
- Moved packages required only for reports to
Suggestsfield inDESCRIPTIONfile.
New features
- Added irradiation conditions input to dose-effect fitting modules.
- Reports include conditional formatting of
u-value and other formatting refinements. - Added
biodosetools_versionelement to Shiny App’s exported*-fitting-data-YYY-MM-DD.rdsfiles. -
fit()function allows to optionally select"glm"or"maxlik"algorithms. If"glm"if selected, the originaltryCatch()routine will be executed.
Bug fixes
- Fixed unexported
calculate_aberr_var()function. - Stopped using weights in fitting algorithms (
glmandglm.nb). Fixes #20, addresses part of #14 as well. - Fixed aggregated count data column parsing in
fix_count_data_names()function. - Fixed case data parsing issue when
.csvfile is not perfectly formatted. - Fixed issue with manual fitting curve input (fixes #23).
- Fixed bug in
calculate_yield_infimum()where infima were being calculated for yield estimate only (fixes #26). - Fixed wrong calculation of aberrations
XforCkwhenk>=10(fixes #27). - Fixed
fix_count_data_names()to properly correctCk>=C10(related to issue #27). - Added “where” to global variables (see https://github.com/r-lib/tidyselect/issues/201).
New functions
-
inner_column(), to fix padding of boxes inside columns. -
widget_sep(), to insertdiv(class = "widget-sep", br())calls. -
widget_sep_vert()to insertdiv(style = "height: 8px;")calls. -
names_from_model_formula(), to parserhandsontable()Unicode row and column coefficient names. -
parse_model_formula()to get raw and TeX formulae frommodel_formula. -
calculate_trans_rate_sigurdson()andcalculate_trans_rate_manual()to calculate translocation rates. -
calculate_aberr_table()wrapper, to calculate aberration tables for count and cases data. -
init_aberr_table(), to initialise aberration distribution tables in fitting and estimation server modules. -
list_fitting_formulas(), to replace globalglobal_fitting_formulasobject. -
generalise_fit_coeffs()andgeneralise_fit_var_cov_mat(), used internally in estimation functions instead of usinggeneral_fit_*as parameters.
Function refactoring
- Refactored
get_decision_threshold()function tocalculate_decision_threshold(), and addedcalculate_decision_threshold_table()wrapper function. - Refactored
calculate_decision_threshold_*()functions to removeinputargument. - Refactored
get_*()translocation functions tocalculate_*()for better consistency. - Refactored
get_*_dose_curve()functions toplot_*_dose_curve()for more clarity. - Refactored
get_model_statistics()tocalculate_model_stats(). - Refactored
get_fit_*()functions tofit()andfit_*_method().
Improvements
- Added Oliveira citation on
get_fit_maxlik_method()function. - Fixed Gaëtan’s name order in citation and contributors list.
- Updated README and About body text.
- Renamed source R files for better naming consistency.
- Changed structure of modules to
mod_<calc_type>_<aberration>_*(). - Generalised
get_model_statistics()function so that localget_model_statistics()definition could be removed frommod_estimate_fit_curve_server()module. - Multiple (18 files)
<aberration>-<module>-<format>.Rmdreport templates have been merged into<module>-<format>.Rmd(4 files). - Use
correct_negative_vals()to ensure correct dose estimation whenX < Xcin translocations assay. - Replaced all
*_at()and*_if()occurrences by their {dplyr} 1.0.0 equivalents.
UI Improvements
- Replaced
column(width = X)calls bycol_X()in UI modules. - Added
tabitem-containerclass totabItem()page containers for fixedmax-widthwhile keeping responsive UI. - Added
col-inner-textinput-*CSS classes for Irradiation conditionstextInput()widgets’ containers. - Added
sep-widget-downloadandsep-widget-formatCSS classes to unify download and format select buttons into a single widget.
biodosetools 3.4.0 (2020-10-11)
- Removed all non-ASCII characters.
- Major overhaul of reports.
- Added “Report bug” button on home screen and cleaned up
dashboard_*()code. - Removed dependencies on {stringr} package.
- Initial
utils::citation()support via CITATION file. - Minimal version of R bumped to 3.5.0.
- Minimal version of {dplyr} bumped to 1.0.0.
Bug fixes
- Replaced
C,α,βvariables (and derivatives) bycoeff_C,coeff_alpha,coeff_beta. - Fixed error in genome_fraction parsing for translocations in
estimate_partial_dolphin(). - Fixed count/case data standard error column names replacements.
- Fixed minipage issue when using more than 12 columns in {knitr} tables with column name replacements, by using
format = "latex", escape = FALSEparameters inkable()call. - Suppress YAML warning when using
!exprin PDF reports. See https://github.com/rstudio/rstudio/issues/7545.
New functions
-
fix_coeff_names(), to fix coefficient names in reports. -
fix_count_data_names(), to fix count/case data column names in PDF reports. -
to_title(), to replacestringr::str_to_title()using base R.
biodosetools 3.3.1 (2020-10-07)
Bug fixes
- Count and case data calculations are performed using
calculate_aberr_*()functions. Fixes #8. - Fixed missing {dplyr} namespace in
n()function call. - Fixed mismatched use of
awesomeCheckbox()andswitchInput()in confounders input.
New functions
-
calculate_aberr_power(), which supersedes internalaberr_calc()function in server modules. -
calculate_aberr_mean(). -
calculate_aberr_var(). -
calculate_aberr_disp_index(). -
calculate_aberr_u_value().
biodosetools 3.3.0 (2020-07-27)
Initial migration of the app into a {golem} R package. This means Biodose Tools is also available as a regular R package in case the user wants to build their own R scripts. This also reduced lots of code redundancies, and made the code a lot more robust.
New features
- App is now a {golem} R package.
- Migrated UI from {shinydashboard} to {bs4Dash}.
- Modals are now built with {bsplus} instead of {shinyBS}.
- Functions and internal data are documented using {roxygen2}.
- Added {pkgdown} support to build {biodosetools}’s website automatically.
- All custom theming is done through SASS and CSS instead of R code injection.
New functions
- New
include_help()for help dialogues - New
help_modal_button()function to help build modal trigger buttons on boxes’ titles. - New
load_rmd_report()function to use in serverdownloadHandler(). - Moved
get_genome_fraction()as its own exported function.
Fixes
- Fixed #7. Overestimate error of lambda when dispersion is smaller than 1.
- Fixed missing icon on sidebar.
- Fixes in collapse button paddings.
- Fixed
tabBoxparameters. - Using
rlang::.data$to avoid “no visible binding for global variable” warnings. - Fixed
bsplus::bs_modal()calls inoutput$estimate_results_ui. - Removed input as parameter in calculation functions.
- Fixed style of help button on
box/tabBoxheaders. - Updated old “biodosimetry-uab” URLs to “biodosetools-team”.
Improvements
- Stop exporting auxiliary
include*()functions used on the app only. - Moved
widget_label()to widgets.R. - Refactored
inner_column()function. - Refactored UI modules names.
- Refactored server functions and renamed R scripts.
- Updated reports.
- Using
load_rmd_report()onmod_estimate_results_server()module. - Added DNA Content Fractions of Human Chromosomes (IHGSC) data.
- Updated
dna_content_fractionscall onmod_trans_fraction_to_full_genome_server()module. - Added support for
tabBoxonhelp_modal_button()widget. - Added indentation to all module
rhandsontable()calls. - Stop exporting
get_decision_threshold()function temporarily. - “Stains color options” boxes don’t use
inner_column()anymore. - Updated
NEWS.mdheaders so they can be parsed by {pkgdown}.
UI Improvements
- Removed
experiment_selectselectInput()from sidebar. Every assay is listed on the “Aberration assays”sidebarMenu(). - Loading all UI modules in
dashboard_body(). - Navbar now uses
rightUiandleftUiparameters, as well asskin = "light". - Switched from
shinyBS::bsButton()toshiny::actionButton()for calling modal dialogues. - New CSS style sheet for {shinydashboard}.
- Deleted old CSS files for {bs4Dash}.
- New fonts CSS stylesheet.
- New CSS stylesheets for fixes of existing classes and definition of custom classes.
- Added
hot-improvedCSS class forrHandsontableOutput(). - Moved custom widgets classes from
theming.Rtocustom.css. - Tweaks in
box,awesome-checkbox, and sidebar submenus CSS styles. - Replaced
theme_button_status()function by proper SASS to CSS compilation. - Finished SASS box header colors.
- Using SASS modules to reconstruct
biodose_style.css. - Moved treeview-menu style to
sidebar.scss. - Added checkboxes SASS style.
- Added missing
col-inner-*CSS classes. - Added app version on sidebar footer with custom
sticky-footerCSS class. - Switched to a single stylesheet, being everything built by SASS modules.
- Added custom style to
radiobuttons.
biodosetools 3.2.0 (2020-02-11)
All calculations functions previously provided in inst/app/calcs have been made proper functions on the package.
New functions
-
calculate_yield()new wrapper ofyield_fun(),R_factor(), andyield_error_fun(). -
calculate_yield_infimum()function to calculate infima of yields given a curve. -
project_yield()merged version of theproject_yield_estimate(),project_yield_lower(), andproject_yield_upper()functions.
“New” functions
-
get_decision_threshold(). -
get_fit_dose_curve(). -
get_fit_glm_method(). -
get_fit_maxlik_method(). -
get_fit_results(). -
get_model_statistics(). -
prepare_maxlik_count_data(). -
AIC_from_data(). -
correct_boundary(). -
correct_conf_int(). -
correct_negative_vals(). -
correct_yield(). -
get_estimated_dose_curve(). -
protracted_g_function(). -
R_factor(). -
yield_error_fun(). -
yield_fun(). -
estimate_hetero(). -
estimate_partial_dolphin(). -
estimate_whole_body_delta(). -
estimate_whole_body().
biodosetools 3.1.0 (2019-10-26)
Unofficial release (wasn’t changed on DESCRIPTION file). This includes some of the changes discussed with David in Stockholm (ERPW19).
New features
- Made var-cov matrix optional on dose estimation inputs.
- Fixed calculations to make var-cov matrix optional on dose estimation inputs.
biodosetools 3.0.0 (2019-10-12)
The app is now available as an R package on GitHub (not submitted to CRAN yet).
New functions
-
runApp()for launching Biodose Tools. -
%>%imported from {magrittr}.
biodosetools 2.1.0 (2019-07-27)
New features
- Initial implementation of micronuclei, adding support in UI and server functions.
- Implemented negative binomial fitting calculation for micronuclei count data.
- Initial detection limit implementation for translocations.
- Added DOCX support for dicentrics and translocations.
Fixes
- Fixed
colwidths for detection limits. - Fixed unnecessary recalculation of
num_colsfor chromosome tables in translocations modules. - New subdirectory structure for help dialogues.
- Added buttons and example tables in help dialogues.
- Updated documentation link.
biodosetools 2.0.0 (2019-07-17)
New features
- Added manual input of translocations name.
- Implemented dynamic calculation of hot width for counts, cases, and chromosome data tables.
- Implemented manual input of translocation frequency to be subtracted from the observed yield.
- Started detection limit calculation in fitting module.
- Implemented Delta method for whole-body estimation.
- Added calculation of standard error of
Fgfor translocations’ dose estimation module.
Fixes
- Fixed dependency of the “Calculate fitting” button in the translocation module.
- Fixed calculations for whole and partial body estimations for translocations module.
- Fixed colors on chromosome hot table example.
- Fix genomic conversion factor not being read when doing fitting.
- Fix
Fp -> ywhen using dicentrics in dose estimation module. - Fixed detection limit calculation.
- Fixed dose estimation in detection limits function.
- Corrected correction of FISH to Full genome when inputting manual fitting curve in dose estimation modules.
- Corrected reading of translocations fit curve values in dose estimation module.
Improvements
- Tweaked variable names and order in cases data for translocations dose estimation.
- Updated
help_colors_dialogfor translocations modules. - New module for auxiliary
rhandsontable()tables used in help dialogues. - New help dialogues for translocations modules.
- Consistent use of
genome_fractionin variables related to the genomic conversion factor/fraction of genome hybridised. - ggplot2 curve generation is now wrapped inside a function on the dose estimation modules.
- Finished confounders help dialogue.
- New aberration calculation method using
purrr::map_df()instead of a nested loops, which is about 10 times faster. - Make clear in translocations dose estimation module that the coefficients are from the full genome.
- Added highly protracted exposure.
- Implemented calculation of detection limits from data.
- Added dose calculation to detection limits section.
- Changed
σto\sigmain help dialogues. - Added units to result tables.
- Code clean-up on delta method for whole-body dose estimation.
- Updated plot CI text generation on legend to account for new Delta method and for separate whole-body & heterogeneous error method selection.
- CONTRIBUTORS.md is now displayed as a modal.
- Using ORCID for authors when possible.
- Updated institution links in contributors files.
UI Improvements
- Improved
side-widget-tallbottom margins. - Moved translocation frequency
selectInput()next to Calculate Fitting button for better UX. - New
hot-improvedCSS class for better hot tables’ formatting. - All hot tables are using
hot-improvedclass now. - New contributors list style and custom CSS style for tables.
- Added experiment/aberration name on tab body title to avoid confusions.
- Improved “About” tab paddings.
- Improve widths of color columns in chromosome tables.
- Narrower color columns in chromosome tables.
- All hot tables’ widths are dynamic or exact now.
- Improved small action buttons style on help dialogues.
- New results color to differentiate from main color.
- Updated UI to adapt for new Delta method for whole-body estimation.
- Updated translocations UI to adapt for new Delta method for whole-body estimation.
- Added CI for Dolphin dose estimation UI.
- Added (work in progress) Micronuclei into UI.
- Hide language selector until shiny-i18n is implemented.
biodosetools 1.2.0 (2019-06-25)
New features
- Start translocations dose estimation module and report.
- Allow using M-Fish color scheme in translocations fitting module.
- Added method to convert from translocations measured by FISH to full genome.
- Implemented confounders modifications for translocations in
generalEstimateCaseHotTable()module.
Improvements
- New chromosome table structure.
transChromosomeTable()andtransFractionToFullGenomeCalc()have been moved totransGeneralModule.R, as they are reused in the dose estimation module. - Using new chromosome table UI and server modules for translocations dose estimation.
- Merged “repeated” fitting modules into a
generalFittingModules.Rfile. - Merged
*FittingResults()modules intogeneralFittingResults()module. - Updated translocations fitting report to new chromosome table structure.
- New
generalEstimateFittingCurveHotTables()andgeneralEstimateFittingCurve()modules. - New
globalVariables.Rwithglobal_fitting_formulaslist. - Added translocations-specific code in
generalEstimateFittingCurve()module to take into account used translocation frequency. - New inputs for used translocation frequency and genomic conversion factor in manual fitting input in dose estimation module.
- Moved dose estimation to
generalEstimateResults()module. - Modify translocations
(X - Xt)for whole-body and partial-body dose estimation. - Added readOnly status to
Xt,yt,yt_errvariables onrhandsontable()for translocations case data.
UI improvements
- New
innerColumnto use inside cards/boxes. - New
widgetLabel()function for labels above widgets without default label. - Replaced old labels by new
widgetLabel()function. - Finished confounders UI in translocations dose estimation module.
- New
mySwichInput()function based onshinyWidgets::switchInput()withsideLabeland custom status colors. - Moved from
awesomeCheckbox()tomySwitchInput()in all UI modules. - Moved fitting curve input in translocations’ dose estimation module to the top.
biodosetools 1.1.0 (2019-06-15)
New features
- Conditional tabs in sidebar by implementing
bs4MyConditionalSidebarMenuItem()function. - Implemented AIC calculation for different dose estimation assessments.
- Added ZIP archive with sample data for testing.
- New dynamic
bs4TabCard()usingrenderUI()andsession$ns()to show different tabs depending on user input. - Implemented manual calculation of case parameters (
N,X,y,y_est,DI,u) in dose estimation module.
Improvements
- Disabled automatic calculation of
N,X,DI,uto avoid broken input issues when running the deployed app. - Added
CONTRIBUTORS.mdfile. - Removed {fontawesome} package requirement.
- Added translocation frequency and genomic conversion factor to translocations fitting report.
- Chromosome table included in reports.
- Major rewrite of {ggplot2} plot in dose estimation module.
- Added Dolphin CI info into plot when using partial-body assessment.
- Changed display of CI in plot for dose estimation.
- Genomic conversion factor is used in
transFittingResults()module for calculations instead of modifying the value ofNintransFittingHotTable(). - Added theoretical calculation of model-specific statistics (
glmmethod) on fitting module. - Added renormalisation of data for proper calculation of model-specific statistics in fitting module.
- Added theoretical model-specific statistics calculation for constraint
maxlikoptimization method in fitting module. - Added global
get_model_statistics()to translocations fitting module.
UI improvements
- Cleaner version of
topButton()for help button and help modals on fitting and dose estimation modules.. - More informative model summary dialogue in fitting module.
- Better output of genomic conversion factor.
- “Partial” is now “Partial-body”. Better titles in dose estimation results card.
- New
bs4MyTabCard()function with topButton and noPadding capabilities.
Fixes
- Fixed problem with fit_formula_raw when using linear model. Disabled
*-no-intmodels until Dolphin can deal with them. - Fixed rendering problem in Firefox (and potentially other browsers) with count data
rhandsontable()using 100% of the card’s height. - Fixed dose estimation
rhandsontables()divs on Firefox havingheight = 100%of the card’s own height. - Fixed height error in cases data table in dose estimation module in Firefox.
- Fixed
glm_results objectissue inget_model_statistics()function.
biodosetools 1.0.0 (2019-05-24)
First public beta for laboratories and research centres.
New features
- Initial support of reports.
- Implemented selection of CI for dose estimation (83%-83% & 95%-95%).
- Added method selection for partial body exposure estimation.
- Fixed formatting of variance covariance matrices when rendered by
rHandsontableOutput(). - Linear models compatibility for partial-body (Dolphin) and heterogeneous dose estimation.
- Experimental version of new Maximum Likelihood Estimation method for dose-effect fitting.
- Manual input of fitting coefficients and var/cov matrix for dose estimation.
Improvements
- Added format/MIME type validation for file inputs.
- Render fitting formula using MathJax.
- Format curve depending on selected assessment/method (use appropriate CI) on dose estimation.
- Check if yield projection into dose is mathematically possible. Negative values of yield or dose are changed to zero as well.
- Added modification to Merkle’s yield error function when using protracted exposures.
- Implemented protracted exposure for partial body dose estimation.
- Added automatic Poisson/quasi-Poisson selection on fitting.
- Correct p-values depending on fitting model dispersion.
- Added automatic correction of confidence intervals to use “simplified” Merkle’s method if necessary.
